The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity
نویسندگان
چکیده
The phytochemical analysis of the polar extracts of Cedrus brevifolia needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (1-3), one hydrolysable tannin (4), eleven phenolic derivatives (5-15) and one apocarotenoid (16), while from the methanol: water (5:1) extract we isolated four flavonoids (17-20). Chemical structures of all isolated compounds were determined by 1D, 2D-NMR (1 Dimension, 2 Dimensions Nuclear Magnetic Resonance) and UV-Vis (Ultraviolet-Visible) spectroscopy. Furthermore, the antioxidant potentials and the anti-inflammatory activities of both crude extracts and isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition, and soybean LOX inhibition assays. This is the first report on the chemical profile of C. brevifolia needles. Catechin was the main compound derived from the methanol extract. According to our results, 4-O-β-d-glucopyranyl trans-p-coumaric acid and taxifolin were the most active ingredients.
منابع مشابه
Evaluation of Antilipidperoxidation, Α-Amylase and Lipase Inhibitory Activity of Boswellia Ovalifoliolata Bal. Henry
The objective of the present study was to determine the antilipidperoxidation and in vitro α-amylase and lipase inhibitory activity of the Boswellia ovalifoliolata Bal Henry (BOB) extract. The polyphenolic compounds, flavonoids, and tannins content of the extracts were estimated by spectrophotometry. Antioxidant activity on goat liver lipid peroxidation and linoleic acid was d...
متن کاملAntioxidant Activity of Otostegia persica (Labiatae) and its Constituents
The antioxidant activity of the different extracts and fractions of aerial parts of Otostegia persica (Burm.) Boiss. were evaluated using beta-carotene bleaching and lipid peroxidation methods. The inhibitory activity of the plant extracts on the peroxidation of linoleic acid were measured by ferric thiocyanate method in comparison to methanolic extracts of Green tee, Ginkgo biloba, Vit.E and ...
متن کاملAntioxidant Activity of Otostegia persica (Labiatae) and its Constituents
The antioxidant activity of the different extracts and fractions of aerial parts of Otostegia persica (Burm.) Boiss. were evaluated using beta-carotene bleaching and lipid peroxidation methods. The inhibitory activity of the plant extracts on the peroxidation of linoleic acid were measured by ferric thiocyanate method in comparison to methanolic extracts of Green tee, Ginkgo biloba, Vit.E and ...
متن کاملAnalgesic, Anti- inflammatory, Anti- lipoxygenase Activity and Characterization of Three Bioactive Compounds in the Most Active Fraction of Leptadenia reticulata (Retz.)Wight & Arn. – A Valuable Medicinal Plant
Leptadenia reticulata was reported to be used for several medicinal purposes. The present study was undertaken to evaluate anti-inflammatory, analgesic and lipid peroxidation inhibition activities of L. reticulata. The anti-inflammatory assay was performed by λ-carrageenan and formalin induced paw edema test. Pro inflammatory mediators (IL2, IL6, TNF-α) in serum of treated and control organism ...
متن کاملAnalgesic, Anti- inflammatory, Anti- lipoxygenase Activity and Characterization of Three Bioactive Compounds in the Most Active Fraction of Leptadenia reticulata (Retz.)Wight & Arn. – A Valuable Medicinal Plant
Leptadenia reticulata was reported to be used for several medicinal purposes. The present study was undertaken to evaluate anti-inflammatory, analgesic and lipid peroxidation inhibition activities of L. reticulata. The anti-inflammatory assay was performed by λ-carrageenan and formalin induced paw edema test. Pro inflammatory mediators (IL2, IL6, TNF-α) in serum of treated and control organism ...
متن کامل